Publications
440 results
440 results
2025
LaFleur M, Milling L, Prathima P, Li V, Lemmen A, Streeter I, Heisig PKS, Derosia N, Riffo E, Xu H, et al. A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity. Nature Immunology. 2025;26. doi:10.1038/s41590-025-02231-6
LaFleur M, Milling L, Prathima P, Li V, Lemmen A, Streeter I, Heisig PKS, Derosia N, Riffo E, Xu H, et al. A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity. Nature Immunology. 2025;26. doi:10.1038/s41590-025-02231-6
2024
Milling L, Markson S, Tjokrosurjo Q, Derosia N, Streeter I, Hickok G, Lemmen A, Nguyen T, Prathima P, Fithian W, et al. Framework for in vivo T cell screens. J Exp Med. 2024;221(4). doi:10.1084/jem.20230699
Milling L, Markson S, Tjokrosurjo Q, Derosia N, Streeter I, Hickok G, Lemmen A, Nguyen T, Prathima P, Fithian W, et al. Framework for in vivo T cell screens. J Exp Med. 2024;221(4). doi:10.1084/jem.20230699
Burke K, Chaudhri A, Freeman G, Sharpe A. The B7:CD28 family and friends: Unraveling coinhibitory interactions. Immunity. 2024;57(2):223–244. doi:10.1016/j.immuni.2024.01.013
Burke K, Chaudhri A, Freeman G, Sharpe A. The B7:CD28 family and friends: Unraveling coinhibitory interactions. Immunity. 2024;57(2):223–244. doi:10.1016/j.immuni.2024.01.013
Cohen J, Gouirand V, Macon C, Lowe M, Boothby I, Moreau J, Gratz I, Stoecklinger A, Weaver C, Sharpe A, et al. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche. Sci Immunol. 2024;9(91):eadh0152. doi:10.1126/sciimmunol.adh0152
Cohen J, Gouirand V, Macon C, Lowe M, Boothby I, Moreau J, Gratz I, Stoecklinger A, Weaver C, Sharpe A, et al. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche. Sci Immunol. 2024;9(91):eadh0152. doi:10.1126/sciimmunol.adh0152
LaFleur M, Lemmen A, Streeter I, Nguyen T, Milling L, Derosia N, Hoffman Z, Gillis J, Tjokrosurjo Q, Markson S, et al. X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system. Nat Immunol. 2024;25(1):178–188. doi:10.1038/s41590-023-01689-6
LaFleur M, Lemmen A, Streeter I, Nguyen T, Milling L, Derosia N, Hoffman Z, Gillis J, Tjokrosurjo Q, Markson S, et al. X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system. Nat Immunol. 2024;25(1):178–188. doi:10.1038/s41590-023-01689-6
Georgiev P, Benamar M, Han S, Haigis M, Sharpe A, Chatila T. Regulatory T cells in dominant immunologic tolerance. J Allergy Clin Immunol. 2024;153(1):28–41. doi:10.1016/j.jaci.2023.09.025
Georgiev P, Benamar M, Han S, Haigis M, Sharpe A, Chatila T. Regulatory T cells in dominant immunologic tolerance. J Allergy Clin Immunol. 2024;153(1):28–41. doi:10.1016/j.jaci.2023.09.025
2023
Denize T, Jegede O, Matar S, El Ahmar N, West D, Walton E, Bagheri AS, Savla V, Nabil Laimon Y, Gupta S, et al. PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear Cell Renal Cell Carcinoma Patients. Clin Cancer Res. 2023. doi:10.1158/1078-0432.CCR-23-2274
Denize T, Jegede O, Matar S, El Ahmar N, West D, Walton E, Bagheri AS, Savla V, Nabil Laimon Y, Gupta S, et al. PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear Cell Renal Cell Carcinoma Patients. Clin Cancer Res. 2023. doi:10.1158/1078-0432.CCR-23-2274
Rowe J, Elia I, Shahid O, Gaudiano E, Sifnugel N, Johnson S, Reynolds A, Fung M, Joshi S, LaFleur M, et al. Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade. Cancer Discov. 2023;13(12):2566–2583. doi:10.1158/2159-8290.CD-22-1301
Rowe J, Elia I, Shahid O, Gaudiano E, Sifnugel N, Johnson S, Reynolds A, Fung M, Joshi S, LaFleur M, et al. Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade. Cancer Discov. 2023;13(12):2566–2583. doi:10.1158/2159-8290.CD-22-1301
Collier J, Pauken K, Lee C, Patterson D, Markson S, Conway T, Fung M, France J, Mucciarone K, Lian C, et al. Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice. J Exp Med. 2023;220(10). doi:10.1084/jem.20221920
Collier J, Pauken K, Lee C, Patterson D, Markson S, Conway T, Fung M, France J, Mucciarone K, Lian C, et al. Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice. J Exp Med. 2023;220(10). doi:10.1084/jem.20221920
Kurmi K, Liang D, Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris I, Yao C-H, Park JS, et al. Metabolic modulation of mitochondrial mass during CD4 T cell activation. Cell Chem Biol. 2023;30(9):1064–1075.e8. doi:10.1016/j.chembiol.2023.08.008
Kurmi K, Liang D, Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris I, Yao C-H, Park JS, et al. Metabolic modulation of mitochondrial mass during CD4 T cell activation. Cell Chem Biol. 2023;30(9):1064–1075.e8. doi:10.1016/j.chembiol.2023.08.008
Park JS, Gazzaniga F, Kasper D, Sharpe A. Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy. Exp Mol Med. 2023;55(9):1913–1921. doi:10.1038/s12276-023-01075-0
Park JS, Gazzaniga F, Kasper D, Sharpe A. Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy. Exp Mol Med. 2023;55(9):1913–1921. doi:10.1038/s12276-023-01075-0
Bod L, Kye Y-C, Shi J, Triglia ET, Schnell A, Fessler J, Ostrowski S, Von-Franque M, Kuchroo J, Barilla R, et al. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature. 2023;619(7969):348–356. doi:10.1038/s41586-023-06231-0
Bod L, Kye Y-C, Shi J, Triglia ET, Schnell A, Fessler J, Ostrowski S, Von-Franque M, Kuchroo J, Barilla R, et al. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature. 2023;619(7969):348–356. doi:10.1038/s41586-023-06231-0