Join Us

Sharpe lab is always happy to hear from highly motivated individuals interested in T cell costimulation and immunoregulation. We are dedicated to fostering a collaborative environment and welcome individuals with similar attitudes to join our lab.

Postdoctoral Fellows: We welcome candidates with previous experience particularly in the areas of autoimmunity, immune tolerance or cancer immunology. All candidates should have a track record of high quality biomedical research and a strong publication record.

The successful applicant will have ample opportunities to develop new skills, and will work in a world-class scientific environment with full access to cutting edge tools and technologies.

To apply, please send the following information to

  • Cover letter including the names and contact details for 2-3 references
  • Full CV with a publication list
  • PDF copies of your 2 most recent publications

Computational Biologist

Sharpe lab is seeking a highly motivated individual to join our team as a Computational Biologist. This individual will be mentored by Dr. Arlene Sharpe, an expert in T cell biology and cancer immunology. The lab uses cutting edge techniques including CRISPR/Cas9 genome editing, preclinical mouse models, and single-cell RNA sequencing to improve our understanding of T cell costimulatory pathways in health and disease. The individual will have the opportunity to participate in the analysis of both mouse and human genomic datasets, and identification of novel targets and pathways for cancer immunotherapy and autoimmunity. The individual will have the opportunity to work closely with experimental biologists to interpret and validate findings. The individual will join a pre-existing computational core within the lab, composed of at least one other associate computational biologist and experimental biologists with varying levels of computational experience, all of whom will be involved in day-to-day mentoring, training, and discussions. In addition, we have pre-existing collaborations with dedicated computational biology groups. This individual will have the opportunity to interact and learn from these groups and the larger community at Harvard Medical School and the Broad Institute.

The successful candidate should demonstrate initiative and be invested in the success of research projects. He/she will have enthusiasm for taking a hands-on, problem-solving approach, learning on the job, and collaborating with research scientists and associates in an informal collegial work environment imbued with intellectual rigor. He/she should possess an outstanding academic record and strong communication skills, demonstrate innovative and analytical thinking, and enjoy working in an interdisciplinary team. The successful candidate should have the ability to design algorithms, apply statistical methods, innovate ways to analyze, integrate, visualize, and interpret a wealth of systems data that will directly inform discovery experiments and target advancement projects, requiring development of core domain knowledge in genetics, molecular biology, immunology, and computational biology. The successful candidate also should demonstrate experience with multi-tasking and have the ability to work independently as well as part of a team, and possess meticulous work habits with careful attention to detail. This work will be central to several major research projects, and co-authorship on high-impact publications is expected.

Basic Qualifications

  • Masters degree in biological sciences or a related field required
  • 5+ years experience

Additional Qualifications and Skills

  • Background knowledge in computational biology preferred
  • Strong computational and quantitative skills
  • Strong programming skills and experience in algorithm development (using Python, R, Matlab, etc.)
  • Coursework in Statistics
  • Excellent oral and written English communication skills
  • Ability to solve complex problems

To apply, please submit an application through the Harvard Careers website. (Job posting 53669BR)


Research Scientist
Project: Discovering novel immunotherapy targets for cancer

The Sharpe Lab at Harvard Medical School has created the CHIME (CHimeric IMmune Editing) system for using CRISPR-based in vivo screening to discover novel cancer immunotherapy targets. This project is performed by a multidisciplinary team of research scientists and research technicians who conduct in vivo screens in preclinical murine cancer models, validation/mechanism studies, and technology development centered on in vivo perturbation of immune cells. The overall aim of this project to improve our understanding of mechanisms of sensitivity of tumors to immunotherapy.

We seek a motivated, experienced, and creative immunologist to join our team as a Research Scientist and lead a self-directed project that interfaces with these aims. The candidate will pursue his/her own project within the group working with the existing research team. The candidate must have a strong background in immunology and cancer biology research; experience in animal models required. The ideal candidate will also possess superior experimental planning and execution skills, an open mind, the ability to mentor and manage research technicians, and a strong desire to collaborate and develop new technologies.         

Harvard Medical School offers an outstanding working environment. The workplace culture is exciting, collaborative, and supports a healthy work-life balance. Harvard offers a comprehensive benefits package:

Principal Duties And Responsibilities

  • Develop, lead, and execute research projects independently
  • Help to supervise and mentor research technicians
  • Stay up-to-date on literature and think creatively and critically about the project
  • Contribute to the lab through teamwork and discussion
  • Report progress and track deliverables for funding partner

Minimum Qualifications

  • PhD in relevant field (immunology, cancer biology, or similar)
  • Extensive experience with tumor immunology preclinical models
  • Demonstrated scientific contributions to the field
  • Proven ability to efficiently and effectively solve problems

Applicants should send CV to Martin LaFleur at

      Current Graduate Students: Our laboratory is a member of the Program in Immunology and the Biological and Biomedical Sciences Program (BBS) at Harvard Medical School. To arrange a rotation, please email with a description of your research interests and your preferred rotation dates.

      Prospective Graduate Students: Students interested in pursuing PhD studies within the laboratory should apply to the Program in Immunology or the Biological and Biomedical Sciences Program (BBS) at Harvard Medical School.

      Undergraduate Students: Students interested in pursuing an undergraduate thesis project should email a description of your research interests along with information about your degree program and university affiliation to

      Undergraduate students looking for summer internships are encouraged to apply to the Harvard Medical School Undergraduate Immunology Summer Program.

      We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.