Join Us

Sharpe lab is always happy to hear from highly motivated individuals interested in T cell costimulation and immunoregulation. We are dedicated to fostering a collaborative environment and welcome individuals with similar attitudes to join our lab.

Postdoctoral Fellows: We are actively looking for postdoctoral fellows with the following experience.

Cellular and Molecular Immunology: We welcome candidates with previous experience particularly in the areas of autoimmunity, immune tolerance or cancer immunology.

All candidates should have a track record of high quality biomedical research and a strong publication record.

The successful applicant will have ample opportunities to develop new skills, and will work in a world-class scientific environment with full access to cutting edge tools and technologies.

To apply, please send the following information to

  • A full CV with a publication list
  • Cover letter including the names and contact details for 2-3 references
  • PDF copies of your 2 most recent publications


Research Scientist                                                                                                                                                                                                              Project: Discovering novel immunotherapy targets for cancer

Job Description

The Sharpe Lab at Harvard Medical School has created the CHIME (CHimeric IMmune Editing) system for using CRISPR-based in vivo screening to discover novel cancer immunotherapy targets. This project is performed by a multidisciplinary team of research scientists and research technicians who conduct in vivo screens in preclinical murine cancer models, validation/mechanism studies, and technology development centered on in vivo perturbation of immune cells. The overall aim of this project to improve our understanding of mechanisms of sensitivity of tumors to immunotherapy.

We seek a motivated, experienced, and creative immunologist to join our team as a Research Scientist and lead a self-directed project that interfaces with these aims. The candidate will pursue his/her own project within the group working with the existing research team. The candidate must have a strong background in immunology and cancer biology research; experience in animal models required. The ideal candidate will also possess superior experimental planning and execution skills, an open mind, the ability to mentor and manage research technicians, and a strong desire to collaborate and develop new technologies.         

Harvard Medical School offers an outstanding working environment. The workplace culture is exciting, collaborative, and supports a healthy work-life balance. Harvard offers a comprehensive benefits package:

Principal Duties And Responsibilities

  • Develop, lead, and execute research projects independently
  • Help to supervise and mentor research technicians
  • Stay up-to-date on literature and think creatively and critically about the project
  • Contribute to the lab through teamwork and discussion
  • Report progress and track deliverables for funding partner

Minimum Qualifications

  • PhD in relevant field (immunology, cancer biology, or similar)
  • Extensive experience with tumor immunology preclinical models
  • Demonstrated scientific contributions to the field
  • Proven ability to efficiently and effectively solve problems

Applicants should send CV to Martin LaFleur at

      Current Graduate Students: Our laboratory is a member of the Program in Immunology and the Biological and Biomedical Sciences Program (BBS) at Harvard Medical School. To arrange a rotation, please email with a description of your research interests and your preferred rotation dates.

      Prospective Graduate Students: Students interested in pursuing PhD studies within the laboratory should apply to the Program in Immunology or the Biological and Biomedical Sciences Program (BBS) at Harvard Medical School.

      Undergraduate Students: Students interested in pursuing an undergraduate thesis project should email a description of your research interests along with information about your degree program and university affiliation to

      Undergraduate students looking for summer internships are encouraged to apply to the Harvard Medical School Undergraduate Immunology Summer Program.

      We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.