Join Us

Sharpe lab is always happy to hear from highly motivated individuals interested in T cell costimulation and immunoregulation. We are dedicated to fostering a collaborative environment and welcome individuals with similar attitudes to join our lab.

Staff Scientist I: The Sharpe laboratory at Harvard Medical School is currently seeking a highly motivated individual to support research that uses mouse perturbation technology for conducting forward genetic screens for discovery of novel immunotherapy targets for cancer. This individual will lead and execute sub-projects in collaboration with the overall project lead. This individual will participate in writing papers and grant proposals and will give presentations internally, to funding partners, and at conferences.

The duties of this position will include but are not limited to:

  1. Directing and implementing sub-projects within overall project
  2. Managing team of junior technicians to achieve project goals
  3. Planning, scheduling, and coordinating detailed phases of projects
  4. Collecting, analyzing, and interpreting data
  5. Identifying and resolving technological and methodical problems, troubleshooting when necessary
  6. Performing experiments to further project goals
  7. Summarizing data, presenting data weekly at lab meeting
  8. Presenting data directly to project lead weekly
  9. Participating in writing papers and grants
  10. Presenting data at conferences and to funding partners

Applicant requirements include:

Education: PhD required in related discipline.

Skills and Experience: At least 5 years of laboratory experience required. Demonstrated experience with molecular biology techniques, cell culture, and animals required. Must have proven organizational skills; excellent oral and written communication skills, effective and excellent interpersonal skills; demonstrated ability to oversee junior technicians. Superior ability to make independent judgments of experimental priorities. Well-developed problem solving skills.

Working Conditions: Must possess high level of initiative, with the ability to work independently as well as part of a team.  Demonstrated ability to manage junior technicians. Superior critical thinking, creativity, and investment in the success of research projects. Must be willing to work with mice.

To apply, please send your CV to

Postdoctoral Fellows: We are actively looking for postdoctoral fellows with the following experience.

Cellular and Molecular Immunology: We welcome candidates with previous experience particularly in the areas of autoimmunity, immune tolerance or cancer immunology.

Computational Background: Candidates with previous experience performing computational analysis of large datasets are encouraged to apply. Projects will involve interfacing big data, mouse, and human immunology.

All candidates should have a track record of high quality biomedical research and a strong publication record.

The successful applicant will have ample opportunities to develop new skills, and will work in a world-class scientific environment with full access to cutting edge tools and technologies.

To apply, please send the following information to

  • A full CV with a publication list
  • Cover letter including the names and contact details for 2-3 references
  • PDF copies of your 2 most recent publications

Current Graduate Students: Our laboratory is a member of the Program in Immunology and the Biological and Biomedical Sciences Program (BBS) at Harvard Medical School. To arrange a rotation, please email with a description of your research interests and your preferred rotation dates.

Prospective Graduate Students: Students interested in pursuing PhD studies within the laboratory should apply to the Program in Immunology or the Biological and Biomedical Sciences Program (BBS) at Harvard Medical School.

Undergraduate Students: Students interested in pursuing an undergraduate thesis project should email a description of your research interests along with information about your degree program and university affiliation to

Undergraduate students looking for summer internships are encouraged to apply to the Harvard Medical School Undergraduate Immunology Summer Program.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.