Joseph earned his master’s degree developing high throughput screening strategies to identify novel MHC-I alleles at the La Jolla Institute for Immunology under Dr. Bianca Mothé and Dr. Alessandro Sette. He then earned his PhD in the laboratory of Dr. Christopher Hunter at the University of Pennsylvania, where he demonstrated that PD-1/PD-L1 interactions negatively select against effector Treg cells during primary infectious challenges, resulting in the formation of pathological inflammatory responses. He is currently co-mentored by Dr. Arlene Sharpe at HMS and Dr. Eric Smith at DFCI. His ongoing research involves the utilization of CRISPR/Cas9 screening technology to enhance novel CAR T cell treatments in context of various cancer models. Outside of the lab, he’s a gym rat, dog dad, and anime fan.