Prevention of CAR-T-cell dysfunction

Publication information:

LaFleur M, Miller B, Sharpe. Prevention of CAR-T-cell dysfunction. Nat Biomed Eng. 2020;4(1):16–17.

Abstract

The overexpression of the transcription factor c-Jun improves chimeric-antigen-receptor T-cell functionality and enhances the killing of low-antigen-expressing liquid and solid cancers in mice.

PubMed DOI