Balance and imbalance in the immune system: life on the edge.
Publication information:
Topalian S, Sharpe A. Balance and imbalance in the immune system: life on the edge. Immunity. 2014;41(5):682–4. doi:10.1016/j.immuni.2014.11.005
Abstract
CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.