Chair, Department of Immunology
Director, Mouse Engineering Core
Arlene Sharpe, MD, PhD is the Kolokotrones University Professor at Harvard University and Chair of the Department of Immunology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women’s Hospital, a Member at the Broad Institute of MIT and Harvard, and Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center. She is also the Co-Leader of MassCPR (Massachusetts Consortium on Pathogen Readiness) established in March 2020 by Harvard Medical School to respond to the SARS-CoV-2 pandemic and prepare for emerging pathogens of the future.
Dr. Sharpe earned her MD and PhD degrees from Harvard Medical School and completed her residency in Pathology at Brigham and Women’s Hospital. Dr. Sharpe is a leader in the field of T cell costimulation. Her laboratory has discovered and elucidated the functions of T cell costimulatory pathways, including the immunoinhibitory functions of the CTLA-4 and PD-1 pathways, which have become exceptionally promising targets for cancer immunotherapy. Her laboratory currently focuses on the roles of T cell costimulatory pathways in regulating T cell tolerance, effective antimicrobial and antitumor immunity, and translating fundamental understanding of T cell costimulation into new therapies for autoimmune diseases and cancer.
Dr. Sharpe has published over 400 papers and was listed by Thomas Reuters as one of the most Highly Cited Researchers (top 1%) in 2014-2022 and a 2016 Citation Laureate. She received the William B. Coley Award for Distinguished Research in Tumor immunology in 2014, the Warren Alpert Foundation Prize in 2017 and the SITC Smalley Award in 2020 for her contributions to the discovery of PD-1 pathway. In 2022, she received the FASEB Excellence in Science Lifetime Achievement Award, the AAI Lifetime Achievement Award, and the Rous-Whipple Award from the American Society for Investigative Pathology. Dr. Sharpe is an elected member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Association for Cancer Research, National Academy of Inventors, the Society for Immunotherapy of Cancer and the American Association of Immunologists.
77 Avenue Louis Pasteur, NRB 837
Boston, MA 02115