Publications by Year: 1980

Fields BN, Weiner HL, Drayna DT, Sharpe AH. The role of the reovirus hemagglutinin in viral virulence. Ann N Y Acad Sci. 1980;354 :125-34.
Sharpe AH, Chen LB, Murphy JR, Fields BN. Specific disruption of vimentin filament organization in monkey kidney CV-1 cells by diphtheria toxin, exotoxin A, and cycloheximide. Proc Natl Acad Sci U S A. 1980;77 (12) :7267-71.Abstract
We have examined the effect of diphtheria toxin, Pseudomonas aeruginosa exotoxin A, and cycloheximide on the CV-1 cell cytoskeleton. Within a few hours after producing an inhibition of cellular protein synthesis, all these agents specifically disrupted the organization of the vimentin filament system with no discernable effect on microtubules or microfilaments during the period of observation. Furthermore, just as the inhibition of protein synthesis by cycloheximide is reversible, so was the disruption of vimentin filaments by cycloheximide.