%0 Journal Article %J Nat Immunol %D 2001 %T SAP controls T cell responses to virus and terminal differentiation of TH2 cells. %A Wu, C. %A Nguyen, K B %A Pien, G C %A Wang, N. %A Gullo, C %A Howie, D %A Sosa, M R %A Edwards, M J %A Borrow, P %A Satoskar, A R %A Sharpe, A. H. %A Biron, C A %A Terhorst, C. %K Animals %K Carrier Proteins %K CD4-Positive T-Lymphocytes %K CD8-Positive T-Lymphocytes %K Cell Differentiation %K Cytokines %K Immunoglobulin E %K Interferon-gamma %K Intracellular Signaling Peptides and Proteins %K Leishmaniasis, Cutaneous %K Liver %K Lymphocytic Choriomeningitis %K Lymphoproliferative Disorders %K Mice %K Mice, Mutant Strains %K Signal Transduction %K Spleen %K T-Lymphocytes %K Th2 Cells %X SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency. SAP-deficient mice infected with lymphocytic choriomeningitis virus had greatly increased numbers of CD8+ and CD4+ interferon-gamma-producing spleen and liver cells compared to wild-type mice. The immune responses of SAP-deficient mice to infection with Leishmania major together with in vitro studies showed that activated SAP-deficient T cells had an impaired ability to differentiate into T helper 2 cells. The aberrant immune responses in SAP-deficient mice show that SAP controls several distinct key T cell signal transduction pathways, which explains in part the complexity of the XLP phenotypes. %B Nat Immunol %V 2 %P 410-4 %8 2001 May %G eng %N 5 %1 http://www.ncbi.nlm.nih.gov/pubmed/11323694?dopt=Abstract %R 10.1038/87713