%0 Journal Article %J Immunity %D 2014 %T Balance and imbalance in the immune system: life on the edge. %A Topalian, Suzanne L %A Sharpe, Arlene H %K Animals %K CTLA-4 Antigen %K Female %K Germ-Line Mutation %K Haploinsufficiency %K Humans %K Immune System Diseases %K Immunity %K Male %X CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy. %B Immunity %V 41 %P 682-4 %8 2014 Nov 20 %G eng %N 5 %1 http://www.ncbi.nlm.nih.gov/pubmed/25517610?dopt=Abstract %R 10.1016/j.immuni.2014.11.005