@article {543121,
	title = {A negative regulatory function of B7 revealed in B7-1 transgenic mice.},
	journal = {Immunity},
	volume = {1},
	number = {5},
	year = {1994},
	month = {1994 Aug},
	pages = {415-21},
	abstract = {To analyze the functions of T cell costimulators in vivo, we have constructed a transgenic mouse strain that constitutively expresses murine B7-1 on mature B cells. Antibody responses to T-dependent hapten-protein conjugates and serum immunoglobulin levels are markedly depressed in B7-1 transgenic mice. This immune deficiency is not due to an intrinsic B cell defect, as antibody responses to T-independent hapten conjugates are normal. Furthermore, treatment with anti-B7-1 restores the capacity of transgenic mice to respond to hapten-protein conjugates, demonstrating that the deficient antibody responses are directly attributable to the expression of B7-1. These results suggest that the temporally regulated expression of costimulators such as B7-1 may contribute to either initiation or down-regulation (feedback inhibition) of T-dependent immune responses in vivo, and that the inhibitory function is dominant in transgenic mice that constitutively express high levels of this costimulator.},
	keywords = {Animals, Antibody Formation, Antigens, CD80, B-Lymphocytes, Base Sequence, Gene Expression, Mice, Mice, Transgenic, Molecular Sequence Data},
	issn = {1074-7613},
	author = {Sethna, M P and Van Parijs, L and Sharpe, A. H. and Abbas,A.K. and Freeman, G. J.}
}
