@article {543086, title = {Analysis of lymphocyte costimulation in vivo using transgenic and {\textquoteright}knockout{\textquoteright} mice.}, journal = {Curr Opin Immunol}, volume = {7}, number = {3}, year = {1995}, month = {1995 Jun}, pages = {389-95}, abstract = {The use of transgenic technologies in the functional evaluation of the contributions of costimulatory pathways to T-cell activation in vivo has recently undergone a rapid expansion. During the past two years, mice deficient in costimulatory molecules and their receptors have been generated. These mice have revealed novel and critical in vivo functions of costimulatory pathways and have provided valuable models in which to test therapeutic strategies involving costimulatory pathway blockade. Transgenic mice constitutively expressing costimulatory molecules have provided insights into their role in peripheral tolerance.}, keywords = {Animals, Antigens, CD, Antigens, CD11, Antigens, CD18, Antigens, CD2, Antigens, CD28, Antigens, CD29, Antigens, CD40, Antigens, CD58, Antigens, CD80, Antigens, Differentiation, Cell Adhesion Molecules, Cell Communication, CTLA-4 Antigen, Immunoconjugates, Integrin alpha4beta1, Integrins, Intercellular Adhesion Molecule-1, Lymphocyte Activation, Lymphocyte Function-Associated Antigen-1, Mice, Mice, Knockout, Mice, Transgenic, Receptors, Immunologic, Receptors, Lymphocyte Homing, Receptors, Very Late Antigen, Signal Transduction, Vascular Cell Adhesion Molecule-1}, issn = {0952-7915}, author = {Sharpe, A. H.} }