@article {543071,
	title = {Differential expression of alternate mB7-2 transcripts.},
	journal = {J Immunol},
	volume = {155},
	number = {12},
	year = {1995},
	month = {1995 Dec 15},
	pages = {5490-7},
	abstract = {The murine B7-2 (mB7-2) costimulatory molecule is expressed on APCs early during the course of an immune response, suggesting that it may play a pivotal role in the decision between T cell activation and anergy. Murine B7-2 mRNA displays a restricted pattern of expression; it is inducible in B cells, T cells, NK cells, and dendritic cells, but constitutively expressed in unstimulated monocytes. The constitutive and inducible expression of mB7-2 on distinct cell types indicates that mB7-2 is regulated differentially. To further characterize mB7-2 transcripts, we employed 5{\textquoteright} rapid amplification of cDNA ends and reverse transcriptase-PCR to examine transcripts expressed in a variety of types of APCs and analyzed the genomic organization of the mB7-2 gene. We report here that the mB7-2 locus consists of 12 exons and demonstrate that exons 1 through 5 can be used in alternative fashions to produce five distinct transcripts, differing in their 5{\textquoteright} untranslated and signal regions. The expression of these transcripts differs in distinct types of APCs and is modulated by stimuli that activate B cells. These results demonstrate that mB7-2 transcripts are differentially regulated in a tissue-specific fashion and in response to activation stimuli.},
	keywords = {Alternative Splicing, Amino Acid Sequence, Animals, Antigen-Presenting Cells, Antigens, CD, Antigens, CD86, Ascitic Fluid, B-Lymphocytes, Base Sequence, Exons, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Polymerase Chain Reaction, Promoter Regions, Genetic, RNA Processing, Post-Transcriptional, RNA, Messenger, Spleen, Transcription, Genetic},
	issn = {0022-1767},
	author = {Borriello, F and Oliveros, J and Freeman, G. J. and Nadler,L.M. and Sharpe, A. H.}
}
