@article {543036,
	title = {Costimulation and autoimmunity.},
	journal = {Curr Opin Immunol},
	volume = {8},
	number = {6},
	year = {1996},
	month = {1996 Dec},
	pages = {822-30},
	abstract = {The past year has seen significant advances in our understanding of the role of the B7-CD28/CTLA-4 pathway in T cell activation and self-tolerance. Recent studies have demonstrated that CTLA-4 is a critical negative regulator of T cell activation and autoreactivity, revealing a previously unsuspected means by which costimulation is involved in the maintenance and breakdown of self-tolerance. Manipulation of this costimulatory pathway in animal models of autoimmunity has shown an important role for this pathway in both the initiation and progression of autoimmune diseases.},
	keywords = {Animals, Autoimmune Diseases, Autoimmunity, Humans, Lymphocyte Activation},
	issn = {0952-7915},
	author = {Tivol, E A and Schweitzer, A N and Sharpe, A. H.}
}
