@article {543006,
	title = {CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.},
	journal = {J Immunol},
	volume = {158},
	number = {11},
	year = {1997},
	month = {1997 Jun 1},
	pages = {5091-4},
	abstract = {Mice lacking CTLA-4 develop a fatal spontaneous lymphoproliferative disease with massive lymphocytic infiltrates and tissue destruction in many organs. CTLA-4-deficient (-/-) splenocytes and lymph node cells proliferate without added stimuli in vitro. We report here that CTLA4Ig treatment of CTLA-4 -/- mice prevents lymphoproliferation and fatal multiorgan tissue damage in vivo and proliferation of CTLA-4 -/- splenocytes and lymph node cells in vitro. Therefore, stimulation via CD28-B7 interactions appears necessary for CTLA-4 -/- T cell proliferation and the production of lymphoproliferative disease in vivo. When CTLA4Ig treatment is terminated, CTLA-4 -/- T cells become activated and lymphoproliferative disease develops. The lack of long term protective effects of CTLA4Ig treatment suggests that CTLA-4 is needed for the induction and or maintenance of tolerance.},
	keywords = {Animals, Antigens, CD, Antigens, Differentiation, Cell Division, CTLA-4 Antigen, Immune Tolerance, Immunoconjugates, Immunosuppressive Agents, Lymphoproliferative Disorders, Mice, Mice, Knockout},
	issn = {0022-1767},
	author = {Tivol, E A and Boyd, S D and McKeon, S and Borriello, F and Nickerson, P and Strom,T.B. and Sharpe, A. H.}
}
