@article {542986,
	title = {Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice.},
	journal = {J Immunol},
	volume = {159},
	number = {11},
	year = {1997},
	month = {1997 Dec 1},
	pages = {5336-44},
	abstract = {T cell activation and tolerance are regulated by interactions between CD28 or CTLA-4 on T cells and B7 costimulatory molecules on APCs. We have generated transgenic mouse strains that constitutively express B7-1 (CD80) at high levels on B cells or T cells or express B7-2 (CD86) on T lymphocytes to examine the consequences of dysregulated B7 expression on T cell responses. The transgene-derived B7 molecules are functional, because B7-1 transgenic B cells are more efficient APCs than are wild-type B cells, and the activation of B7 transgenic T cells is less dependent on exogenous costimulation than that of wild-type T cells. In vivo, constitutive expression of B7 molecules leads to the elimination of immature B cells. The expression of B7 molecules on thymocytes results in the down-regulation of CD28 expression. However, B7 transgenic mice have normal numbers of mature lymphocytes and mount normal T cell responses following immunization with protein Ag. Neither anergy induction nor superantigen-mediated deletion of T cells is altered by the dysregulated expression of B7-1 or B7-2 on B or T lymphocytes in these transgenic strains. Therefore, functionally significant levels of B7 expressed constitutively on mature lymphocytes are not, by themselves, sufficient to abrogate T cell tolerance or induce autoimmune disease.},
	keywords = {Animals, Antigens, CD, Antigens, CD80, Antigens, CD86, B-Lymphocytes, Immune Tolerance, Membrane Glycoproteins, Mice, Mice, Transgenic, T-Lymphocytes},
	issn = {0022-1767},
	author = {Van Parijs, L and Sethna, M P and Schweitzer, A N and Borriello, F and Sharpe, A. H. and Abbas,A.K.}
}
