@article {542971,
	title = {Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells.},
	journal = {J Immunol},
	volume = {161},
	number = {12},
	year = {1998},
	month = {1998 Dec 15},
	pages = {6552-8},
	abstract = {We have previously shown that B7-2 (CD86)-transfected P815 tumor cells elicit tumor-eradicating immunity that leads to the regression of the B7-2+ P815 tumor after transient growth in normal DBA/2 mice. Here, we show that both the B7-2 and B7-1 (CD80) molecules contribute to the eradication of B7-2+ P815 tumors as treatment of the mice with both anti-B7-2 and anti-B7-1 mAb was required to prevent B7-2+ P815 tumor regression. The cells that expressed the B7-1 molecule following inoculation of B7-2+ P815 tumor cells into normal mice were not the tumor cells but rather host APCs including MAC-1+ cells present in the draining lymph nodes. Moreover, B7-1-expressing host APCs were found to be important for the rejection of B7-2+ P815 tumors as anti-B7-2 mAb alone, which was ineffective in preventing B7-2+ P815 tumor rejection by normal wild-type mice, was effective in preventing B7-2+ P815 tumor rejection by mice in which the B7-1 gene was disrupted. Finally, consistent with the importance of B7-1-expressing host APCs for the generation of tumor-eradicating immunity against B7-2+ P815 tumor cells, CD4+ T cells (not only CD8+ T cells) were found to participate in tumor-eradicating immunity against B7-2+ P815 tumor cells. Thus, in addition to eliciting tumor-eradicating immunity directly, B7-2+ P815 tumor cells elicit tumor-eradicating immunity indirectly through B7-1-expressing host APCs that present tumor-associated Ags to CD4+ T cells.},
	keywords = {Animals, Antigen Presentation, Antigen-Presenting Cells, Antigens, CD, Antigens, CD80, Antigens, CD86, Antigens, Neoplasm, CD4-Positive T-Lymphocytes, Cytotoxicity, Immunologic, Female, Mast-Cell Sarcoma, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Mice, Inbred DBA, Recombinant Fusion Proteins, Transfection, Tumor Cells, Cultured, Up-Regulation},
	issn = {0022-1767},
	author = {La Motte, R N and Sharpe, A. H. and Bluestone, J A and Mokyr, M B}
}
