@article {542941,
	title = {B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite.},
	journal = {J Immunol},
	volume = {162},
	number = {7},
	year = {1999},
	month = {1999 Apr 1},
	pages = {4133-9},
	abstract = {T cells require CD28/CTLA-4 costimulatory molecule interactions in addition to Ag-specific signals through the TCR for in vivo effector Th cell function. Some studies have suggested that the ligands for these costimulatory molecules may differentially influence effector T cell function with B7-2 favoring a type 2 response and B7-1 favoring a type 1 response, while other studies have suggested that these molecules may be redundant. The recent development of B7-2-deficient mice permits the direct analysis of the requirement of B7-2 during a type 2 immune response to an infectious pathogen. We have examined, in B7-2-deficient mice, effector Th cell function and the associated type 2 immune response following infection with Heligmosomoides polygyrus, a natural murine parasitic nematode. Elevations in cytokine gene expression and protein secretion were pronounced and comparable in inoculated B7-2-/- and B7-2+/+ mice at day 8 after H. polygyrus inoculation. However, by day 14 after infection, increases in T cell cytokine expression were markedly inhibited in H. polygyrus-inoculated B7-2-/- mice. Furthermore, elevations in serum IgE and germinal center formation were inhibited at later stages of the immune response, while elevations in serum IgG1 persisted. These findings suggest that certain T-dependent components vary in their B7-2-dependency during the type 2 immune response. They further demonstrate that B7-2 interactions are not necessary for the initiation of the type 2 immune response, but are instead required for its progression after the development of effector T cells.},
	keywords = {Animals, Antigens, CD, Antigens, CD86, Cytokines, Digestive System, Fertility, Germinal Center, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Mice, Knockout, Nematospiroides dubius, Strongylida Infections, Th2 Cells},
	issn = {0022-1767},
	author = {Greenwald, R J and Urban, J F and Ekkens, M J and Chen, S. and Nguyen, D and Fang, H and Finkelman, F D and Sharpe, A. H. and Gause, W C}
}
