@article {542921,
	title = {CTLA-4 and T cell activation.},
	journal = {Curr Opin Immunol},
	volume = {11},
	number = {3},
	year = {1999},
	month = {1999 Jun},
	pages = {294-300},
	abstract = {The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Th1/Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.},
	keywords = {Animals, Antigens, CD, Antigens, CD28, Antigens, CD80, Antigens, CD86, Antigens, Differentiation, Apoptosis, Autoimmunity, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Differentiation, Cell Division, CTLA-4 Antigen, Humans, Immune Tolerance, Immunoconjugates, Ligands, Lymphocyte Activation, Membrane Glycoproteins, Receptors, Immunologic, Signal Transduction, T-Lymphocytes, Thymus Gland},
	issn = {0952-7915},
	author = {Oosterwegel, M A and Greenwald, R J and Mandelbrot, D A and Lorsbach, R B and Sharpe, A. H.}
}
