@article {542816,
	title = {Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus.},
	journal = {J Immunol},
	volume = {165},
	number = {6},
	year = {2000},
	month = {2000 Sep 15},
	pages = {3436-43},
	abstract = {The activation of T lymphocytes requires both Ag-mediated signaling through the TCR as well as costimulatory signals transmitted through B7-1 and/or B7-2 with CD28. The interference of B7-mediated costimulatory signals has been proposed as one immunotherapeutic intervention for the prevention autoimmune disease. This study has examined autoantibody responses and autoimmune pathology in a murine model of human systemic lupus erythematosus (SLE), the MRL-lpr/lpr mouse, genetically deficient in B7-1 or B7-2, or in mice treated with B7-1/B7-2 blocking Abs. In contrast to other studies of murine models of SLE, MRL-lpr/lpr mice treated with B7 blocking Abs exhibit strong anti-small nuclear ribonucleoprotein (snRNP) and anti-DNA autoantibody responses with some changes in isotype switching as compared with untreated animals. All MRL-lpr/lpr mice deficient in B7-1 or B7-2 produce anti-snRNP and anti-DNA titers with isotypes virtually identical with wild-type animals. However, the absence of B7-2 costimulation did interfere with the spontaneous activation and the accumulation of memory CD4+ or CD8+ T lymphocytes characteristic of wild-type MRL-lpr/lpr mice. IgG and C3 complement deposition was less pronounced in the kidneys of B7-2 deficient MRL-lpr/lpr mice, reflecting their lessor degree of glomerulonephritis. By comparison, B7-1-deficient MRL-lpr/lpr mice had more severe IgG and C3 deposits in glomeruli.},
	keywords = {Animals, Antibodies, Antinuclear, Antigens, CD, Antigens, CD80, Antigens, CD86, Antigens, Differentiation, B-Lymphocyte, Autoantibodies, Biological Markers, Complement C3, DNA, Immunoglobulin G, Immunoglobulin Isotypes, Immunoglobulin M, Kidney, Lupus Nephritis, Lymphocyte Activation, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Mice, Inbred MRL lpr, Mice, Knockout, Ribonucleoproteins, Small Nuclear, T-Lymphocytes},
	issn = {0022-1767},
	author = {Liang, B and Kashgarian, M J and Sharpe, A. H. and Mamula, M J}
}
