@article {542781,
	title = {CTLA-4 regulates induction of anergy in vivo.},
	journal = {Immunity},
	volume = {14},
	number = {2},
	year = {2001},
	month = {2001 Feb},
	pages = {145-55},
	abstract = {The requirement for CTLA-4 during the induction of peripheral T cell tolerance in vivo was investigated using naive TCR transgenic T cells lacking CTLA-4. CTLA-4(-/-) T cells are resistant to tolerance induction, as demonstrated by their proliferative responses, IL-2 production, and progression into the cell cycle. Following exposure to a tolerogenic stimulus in vivo and restimulation in vitro, wild-type T cells are blocked at the late G1 to S restriction point of the cell cycle. In contrast, CTLA-4(-/-) T cells enter into the S phase of the cell cycle, as shown by downregulation of p27(kip1), elevated cdk2 kinase activity, and Rb hyperphosphorylation. Thus, CTLA-4 has an essential role in determining the outcome of T cell encounter with a tolerogenic stimulus.},
	keywords = {Animals, Antigens, CD, Antigens, Differentiation, Apoptosis, Cell Cycle, Clonal Anergy, CTLA-4 Antigen, Cytokines, DNA-Binding Proteins, Immune Tolerance, Immunoconjugates, In Vitro Techniques, Interleukin-2, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Mice, Knockout, Mice, Transgenic, T-Lymphocytes},
	issn = {1074-7613},
	author = {Greenwald, R J and Boussiotis, V. A. and Lorsbach, R B and Abbas,A.K. and Sharpe, A. H.}
}
