@article {542771,
	title = {SAP controls T cell responses to virus and terminal differentiation of TH2 cells.},
	journal = {Nat Immunol},
	volume = {2},
	number = {5},
	year = {2001},
	month = {2001 May},
	pages = {410-4},
	abstract = {SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency. SAP-deficient mice infected with lymphocytic choriomeningitis virus had greatly increased numbers of CD8+ and CD4+ interferon-gamma-producing spleen and liver cells compared to wild-type mice. The immune responses of SAP-deficient mice to infection with Leishmania major together with in vitro studies showed that activated SAP-deficient T cells had an impaired ability to differentiate into T helper 2 cells. The aberrant immune responses in SAP-deficient mice show that SAP controls several distinct key T cell signal transduction pathways, which explains in part the complexity of the XLP phenotypes.},
	keywords = {Animals, Carrier Proteins, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Differentiation, Cytokines, Immunoglobulin E, Interferon-gamma, Intracellular Signaling Peptides and Proteins, Leishmaniasis, Cutaneous, Liver, Lymphocytic Choriomeningitis, Lymphoproliferative Disorders, Mice, Mice, Mutant Strains, Signal Transduction, Spleen, T-Lymphocytes, Th2 Cells},
	issn = {1529-2908},
	doi = {10.1038/87713},
	author = {Wu, C. and Nguyen, K B and Pien, G C and Wang, N. and Gullo, C and Howie, D and Sosa, M R and Edwards, M J and Borrow, P and Satoskar, A R and Sharpe, A. H. and Biron, C A and Terhorst, C.}
}
