@article {542726,
	title = {Negative co-receptors on lymphocytes.},
	journal = {Curr Opin Immunol},
	volume = {14},
	number = {3},
	year = {2002},
	month = {2002 Jun},
	pages = {391-6},
	abstract = {The past year has seen significant advances in our understanding of critical roles of negative immunoregulatory signals delivered through the B7-CD28 superfamily in regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel insights into the inhibitory functions of CTLA-4. Initial characterization of the PD-1-PD-1-ligand pathway has revealed that this pathway can downregulate TCR- and CD28-mediated signals. Recent studies indicate that ICOS exerts distinct effects at different phases of an immune response: ICOS can inhibit as well as stimulate T cell responses.},
	keywords = {Animals, Antigens, CD, Antigens, CD274, Antigens, CD28, Antigens, CD80, Antigens, Differentiation, Antigens, Differentiation, T-Lymphocyte, Antigens, Surface, Apoptosis Regulatory Proteins, Blood Proteins, CTLA-4 Antigen, Humans, Immunoconjugates, Inducible T-Cell Co-Stimulator Protein, Intercellular Signaling Peptides and Proteins, Membrane Glycoproteins, Peptides, Programmed Cell Death 1 Ligand 2 Protein, Programmed Cell Death 1 Receptor, T-Lymphocytes},
	issn = {0952-7915},
	author = {Greenwald, Rebecca J and Latchman, Yvette E and Sharpe, Arlene H}
}
