@article {542716,
	title = {T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major.},
	journal = {Eur J Immunol},
	volume = {32},
	number = {6},
	year = {2002},
	month = {2002 Jun},
	pages = {1764-72},
	abstract = {The contribution of the costimulatory molecules B7-1 and B7-2 to the in vivo differentiation of Th cells remains controversial. The infection of resistant and susceptible strains of mice with the parasite Leishmania major provides a well-established model for studying in vivo differentiation of CD4+ T cells. We have infected B7-1/B7-2-deficient mice on the BALB/c and 129 background with L. major and subsequently examined different parameters of infection and cytokine responses upon restimulation of lymph node cells in vitro. BALB/c B7-2-deficient and B7-1/B7-2-double deficient mice are resistant to L. major, whereas BALB/c B7-1-deficient mice remain as susceptible as wild-type BALB/c mice. Differential expression of B7-1 and B7-2 can explain the distinct roles observed for these B7 costimulators in L. major infection.},
	keywords = {Animals, Antigens, CD, Antigens, CD28, Antigens, CD80, Antigens, CD86, Cell Differentiation, Disease Susceptibility, Female, Immunoglobulin G, Interferon-gamma, Interleukin-4, Leishmania major, Leishmaniasis, Cutaneous, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, T-Lymphocytes, Helper-Inducer},
	issn = {0014-2980},
	doi = {10.1002/1521-4141(200206)32:6<1764::AID-IMMU1764>3.0.CO;2-V},
	author = {Brown, Julia A and Greenwald, Rebecca J and Scott, Sumi and Schweitzer, A Nicola and Satoskar, Abhay R and Chung, Charles and Schopf, Lisa R and van der Woude, Diane and Sypek, Joseph P and Sharpe, Arlene H}
}
