@article {542666,
	title = {Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo.},
	journal = {J Immunol},
	volume = {169},
	number = {12},
	year = {2002},
	month = {2002 Dec 15},
	pages = {6959-68},
	abstract = {Th2 immune responses to a number of infectious pathogens are dependent on B7-1/B7-2 costimulatory molecule interactions. We have now examined the Th2 immune response to Nippostrongylus brasiliensis (Nb) in B7-1/B7-2(-/-) mice and show that Th2 effector cells develop that can mediate worm expulsion and produce substantial Th2 cytokines comparable with wild-type infected mice; however, in marked contrast, B cell Ag-specific Ab production is abrogated after B7 blockade. To examine the mechanism of T cell activation, OVA-specific DO11.10 T cells were transferred to recipient mice, which were then immunized with a combination of Nb plus OVA or either alone. Only the combination of Nb plus OVA triggered T cell differentiation to OVA-specific Th2 cells, suggesting that Nb acts as an adjuvant to stimulate Ag-specific naive T cells to differentiate to effector Th2 cells. Furthermore, using the DO11.10 TCR-transgenic T cell adoptive transfer model, we show that blocking B7-1/B7-2 interactions does not impair nonparasite Ag-specific DO11.10 Th2 cell differentiation; however, DO11.10 T cell cycle progression and migration to the B cell zone are inhibited.},
	keywords = {Amino Acid Sequence, Animals, Antibodies, Helminth, Antigens, CD, Antigens, CD80, Antigens, CD86, Antigens, Differentiation, B-Lymphocytes, Cell Cycle, Cell Differentiation, Cell Migration Inhibition, Cells, Cultured, CTLA-4 Antigen, Epitopes, T-Lymphocyte, Growth Inhibitors, Immunoconjugates, Immunosuppressive Agents, Injections, Subcutaneous, Interleukin-4, Interphase, Intestinal Mucosa, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Mice, Knockout, Mice, Transgenic, Molecular Sequence Data, Nippostrongylus, Ovalbumin, Peptide Fragments, Strongylida Infections, T-Lymphocyte Subsets, Th2 Cells},
	issn = {0022-1767},
	author = {Liu, Zhugong and Liu, Qian and Pesce, John and Whitmire, Jeannette and Ekkens, Melinda J and Foster, Anthony and VanNoy, Jansie and Sharpe, Arlene H and Urban, Joseph F and Gause, William C}
}
