@article {542616,
	title = {B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].},
	journal = {J Immunol},
	volume = {172},
	number = {1},
	year = {2004},
	month = {2004 Jan 1},
	pages = {34-9},
	abstract = {Although B7 on APCs has a well-recognized role in T cell costimulation, little is known about the functional significance of constitutive and activation-induced B7 expression that also occurs on T cells. To analyze the role of B7 on T cells, B7-1/B7-2-deficient mice (B7 double knockout) and mice overexpressing B7-2 exclusively on T cells (B7-2 transgenic) were used as T cell donors for allogeneic transplant recipients, and graft-vs-host disease (GVHD) was assessed. B7 double-knockout T cells resulted in significant GVHD acceleration compared with wild-type T cells. Conversely, B7-2 transgenic donor T cells mediated reduced GVHD mortality compared with wild-type T cells. Data indicated that B7 expression on T cells down-regulated alloresponses through CTLA-4 ligation. This study is the first to provide definitive in vivo data illustrating the importance of T cell-associated B7 as a negative regulator of immune responses in a clinically relevant murine model of GVHD. The up-regulation of B7 on T cells may be an important component of normal immune homeostasis.},
	keywords = {Animals, Antigen-Presenting Cells, Antigens, CD, Antigens, CD80, Antigens, CD86, Antigens, Differentiation, Bone Marrow Transplantation, CD4-Positive T-Lymphocytes, Cell Communication, CTLA-4 Antigen, Down-Regulation, Graft vs Host Disease, Ligands, Lymphocyte Activation, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Receptors, Interleukin-2, T-Lymphocyte Subsets, Up-Regulation},
	issn = {0022-1767},
	author = {Taylor, Patricia A and Lees, Christopher J and Fournier, Sylvie and Allison, James P and Sharpe, Arlene H and Blazar, Bruce R}
}
