@article {542606,
	title = {The cell surface receptor SLAM controls T cell and macrophage functions.},
	journal = {J Exp Med},
	volume = {199},
	number = {9},
	year = {2004},
	month = {2004 May 3},
	pages = {1255-64},
	abstract = {Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responses and is one of the two receptors for measles virus. Here we show that T cell receptor-induced interleukin (IL)-4 secretion by SLAM(-/-) CD4(+) cells is down-regulated, whereas interferon gamma production by CD4(+) T cells is only slightly up-regulated. Although SLAM controls production of IL-12, tumor necrosis factor, and nitric oxide in response to lipopolysaccharide (LPS) by macrophages, SLAM does not regulate phagocytosis and responses to peptidoglycan or CpG. Thus, SLAM acts as a coreceptor that regulates signals transduced by the major LPS receptor Toll-like receptor 4 on the surface of mouse macrophages. A defective macrophage function resulted in an inability of SLAM(-/-) C57Bl/6 mice to remove the parasite Leishmania major. We conclude that the coreceptor SLAM plays a central role at the interface of acquired and innate immune responses.},
	keywords = {Animals, Antigens, CD, Base Sequence, CD4-Positive T-Lymphocytes, DNA Primers, Glycoproteins, Immunoglobulins, Leishmania major, Leishmaniasis, Cutaneous, Lipopolysaccharides, Macrophages, Peritoneal, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Mutant Strains, Receptors, Antigen, T-Cell, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Cell Surface, Recombinant Proteins, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocytes},
	issn = {0022-1007},
	doi = {10.1084/jem.20031835},
	author = {Wang, Ninghai and Satoskar, Abhay and Faubion, William and Howie, Duncan and Okamoto, Susumu and Feske, Stefan and Gullo, Charles and Clarke, Kareem and Sosa, Miriam Rodriguez and Sharpe, Arlene H and Terhorst, Cox}
}
