@article {542551,
	title = {The B7/CD28 costimulatory family in autoimmunity.},
	journal = {Immunol Rev},
	volume = {204},
	year = {2005},
	month = {2005 Apr},
	pages = {128-43},
	abstract = {Host defense is dependent on the appropriate induction of immune responses. A central concept in immunology is the ability of the immune system to differentiate foreign from self-antigens. The failure of the immune response to recognize foreign pathogens can result in infection and disease in the host. The inappropriate response of the immune system to self-antigens is equally problematic, leading to autoimmune disease. Central and peripheral tolerance mechanisms control self-reactive T-cell responses and protect peripheral tissues from autoimmune attack. This review examines the roles of B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. We also discuss how B7/CD28 pathways influence both T-cell-intrinsic and -extrinsic mechanisms of regulation.},
	keywords = {Animals, Antigens, CD28, Antigens, CD80, Autoimmunity, Dendritic Cells, Immune Tolerance, T-Lymphocytes},
	issn = {0105-2896},
	doi = {10.1111/j.0105-2896.2005.00242.x},
	author = {Keir, Mary E and Sharpe, Arlene H}
}
