@article {542466,
	title = {The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection.},
	journal = {Nat Immunol},
	volume = {8},
	number = {3},
	year = {2007},
	month = {2007 Mar},
	pages = {239-45},
	abstract = {The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate a previously unknown function for PD-L1 on nonhematopoietic cells in protecting tissues from autoimmune attack. PD-1 and its ligands have also been exploited by a variety of microorganisms to attenuate antimicrobial immunity and facilitate chronic infection. Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway.},
	keywords = {Animals, Antigens, CD, Antigens, CD274, Autoimmunity, Communicable Diseases, Humans, Immune Tolerance, Intercellular Signaling Peptides and Proteins, Lymphocyte Activation, Models, Immunological, Programmed Cell Death 1 Ligand 2 Protein},
	issn = {1529-2908},
	doi = {10.1038/ni1443},
	author = {Sharpe, Arlene H and Wherry, E John and Ahmed, Rafi and Freeman, Gordon J}
}
