@article {542366,
	title = {The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.},
	journal = {Nat Immunol},
	volume = {10},
	number = {2},
	year = {2009},
	month = {2009 Feb},
	pages = {167-75},
	abstract = {The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells) and of follicular helper T cells (T(FH) cells). Here we show that ICOS-deficient mice had no defect in T(H)-17 differentiation but had fewer T(H)-17 cells after IL-23 stimulation and fewer T(FH) cells. We also show that T(FH) cells produced IL-17 and that T(FH) cells in ICOS-deficient mice were defective in IL-17 production. Both T(H)-17 and T(FH) cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells.},
	keywords = {Animals, Antigens, Differentiation, T-Lymphocyte, Cell Differentiation, Cell Proliferation, Encephalomyelitis, Autoimmune, Experimental, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Gene Expression Regulation, Inducible T-Cell Co-Stimulator Protein, Interleukin-17, Interleukins, Mice, Mice, Transgenic, Oligonucleotide Array Sequence Analysis, Proto-Oncogene Proteins c-maf, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocyte Subsets, T-Lymphocytes, Helper-Inducer},
	issn = {1529-2916},
	doi = {10.1038/ni.1690},
	author = {Bauquet, Aurelie T and Jin, Hulin and Paterson, Alison M and Mitsdoerffer, Meike and Ho, I-Cheng and Sharpe, Arlene H and Kuchroo, Vijay K}
}
