@article {542291,
	title = {Role of PD-1 in regulating acute infections.},
	journal = {Curr Opin Immunol},
	volume = {22},
	number = {3},
	year = {2010},
	month = {2010 Jun},
	pages = {397-401},
	abstract = {While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by {\textquoteright}helpless{\textquoteright} CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated.},
	keywords = {Acute Disease, Animals, Antigens, Differentiation, Cell Differentiation, Gene Expression Regulation, Humans, Immunologic Memory, Infection, Lymphocyte Activation, Mice, Programmed Cell Death 1 Receptor, T-Lymphocytes},
	issn = {1879-0372},
	doi = {10.1016/j.coi.2010.03.007},
	author = {Brown, Keturah E and Freeman, Gordon J and Wherry, E John and Sharpe, Arlene H}
}
