@article {542201,
	title = {The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1β.},
	journal = {J Immunol},
	volume = {187},
	number = {10},
	year = {2011},
	month = {2011 Nov 15},
	pages = {5328-35},
	abstract = {CBA/J mice infected with the helminth Schistosoma mansoni develop severe CD4 T cell-mediated hepatic granulomatous inflammation against parasite eggs associated with a robust Th17 cell response. We investigated the requisites for Th17 cell development using novel CD4 T cells expressing a transgenic TCR specific for the major Sm-p40 egg Ag, which produce IL-17 when stimulated with live schistosome eggs. Neutralization of IL-23 or blockade of the IL-1 receptor, but not IL-6 neutralization, abrogated egg-induced IL-17 secretion by transgenic T cells, whereas exogenous IL-23 or IL-1β reconstituted their ability to produce IL-17 when stimulated by syngeneic IL-12p40-deficient dendritic cells. Kinetic analysis demonstrated that IL-17 production was initiated by IL-23 and amplified by IL-1β. Significantly, schistosome-infected IL-12p40-deficient or IL-1R antagonist-treated CBA/J mice developed markedly reduced hepatic immunopathology with a dampened egg Ag-specific IL-17 response. These results demonstrate that the IL-23-IL-1-IL-17 axis has a central role in the development of severe schistosome egg-induced immunopathology.},
	keywords = {Animals, Antigens, Helminth, Epitopes, T-Lymphocyte, Helminth Proteins, Interferon-gamma, Interleukin-17, Interleukin-1beta, Interleukin-23, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Transgenic, Schistosoma mansoni, Schistosomiasis mansoni, Th17 Cells},
	issn = {1550-6606},
	doi = {10.4049/jimmunol.1101445},
	author = {Shainheit, Mara G and Lasocki, Krzysztof W and Finger, Eduardo and Larkin, Bridget M and Smith, Patrick M and Sharpe, Arlene H and Dinarello, Charles A and Rutitzky, Laura I and Stadecker, Miguel J}
}
