@article {542151,
	title = {Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1.},
	journal = {Immunity},
	volume = {36},
	number = {6},
	year = {2012},
	month = {2012 Jun 29},
	pages = {1017-30},
	abstract = {Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its immunosuppressive effect, we analyzed genes in T~cells rapidly induced by IL-27. We found that IL-27 priming of naive T~cells upregulated expression of programmed death ligand 1 (PD-L1) in a signal transducer and activator of transcription 1 (STAT1)-dependent manner. When cocultured with naive CD4(+) T~cells, IL-27-primed T~cells inhibited the differentiation of Th17 cells in trans through~a PD-1-PD-L1 interaction. In~vivo, coadministration of~naive TCR transgenic T~cells (2D2 T~cells) with IL-27-primed T~cells expressing PD-L1 inhibited the~development of Th17 cells and protected from severe autoimmune encephalomyelitis. Thus, these data identify a suppressive activity of IL-27, by which CD4(+) T~cells can restrict differentiation of Th17 cells in trans.},
	keywords = {Animals, Antigens, CD274, Bystander Effect, CD4-Positive T-Lymphocytes, Cell Differentiation, Encephalomyelitis, Autoimmune, Experimental, Forkhead Transcription Factors, Gene Expression Regulation, Interferon-gamma, Interleukin-17, Interleukin-1beta, Interleukin-23, Interleukin-6, Interleukins, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Myelin Proteins, Myelin-Oligodendrocyte Glycoprotein, Receptors, Cytokine, T-Lymphocyte Subsets, Th17 Cells, Transforming Growth Factor beta},
	issn = {1097-4180},
	doi = {10.1016/j.immuni.2012.03.024},
	author = {Hirahara, Kiyoshi and Ghoreschi, Kamran and Yang, Xiang-Ping and Takahashi, Hayato and Laurence, Arian and Vahedi, Golnaz and Scium{\`e}, Giuseppe and Hall, Aisling O{\textquoteright}Hara and Dupont, Christopher D and Francisco, Loise M and Chen, Qian and Tanaka, Masao and Kanno, Yuka and Sun, Hong-Wei and Sharpe, Arlene H and Hunter, Christopher A and O{\textquoteright}Shea, John J}
}
