@article {542081,
	title = {PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.},
	journal = {Cell Rep},
	volume = {5},
	number = {5},
	year = {2013},
	month = {2013 Dec 12},
	pages = {1204-13},
	abstract = {Malaria is a highly prevalent disease caused by infection by Plasmodium spp., which infect hepatocytes and erythrocytes. Blood-stage infections cause devastating symptoms and can persist for years. Antibodies and CD4(+) T~cells are thought to protect against blood-stage infections. However, there has been considerable difficulty in developing an efficacious malaria vaccine, highlighting our incomplete understanding of immunity against this disease. Here, we used an experimental rodent malaria model to show that PD-1 mediates up to a 95\% reduction in numbers and functional capacity of parasite-specific CD8(+) T~cells. Furthermore, in contrast to widely held views, parasite-specific CD8(+) T~cells are required to control both acute and chronic blood-stage disease even when parasite-specific antibodies and CD4(+) T~cells are present. Our findings provide a molecular explanation for chronic malaria that will be relevant to future malaria-vaccine design and may need consideration when vaccine development for other infections is problematic.},
	keywords = {Animals, CD8-Positive T-Lymphocytes, Malaria, Mice, Mice, Inbred C57BL, Programmed Cell Death 1 Receptor},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2013.11.002},
	author = {Horne-Debets, Joshua M and Faleiro, Rebecca and Karunarathne, Deshapriya S and Liu, Xue Q and Lineburg, Katie E and Poh, Chek Meng and Grotenbreg, Gijsbert M and Hill, Geoffrey R and MacDonald, Kelli P A and Good, Michael F and Renia, Laurent and Ahmed, Rafi and Sharpe, Arlene H and Wykes, Michelle N}
}
