@article {542021,
	title = {Balance and imbalance in the immune system: life on the edge.},
	journal = {Immunity},
	volume = {41},
	number = {5},
	year = {2014},
	month = {2014 Nov 20},
	pages = {682-4},
	abstract = {CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et~al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.},
	keywords = {Animals, CTLA-4 Antigen, Female, Germ-Line Mutation, Haploinsufficiency, Humans, Immune System Diseases, Immunity, Male},
	issn = {1097-4180},
	doi = {10.1016/j.immuni.2014.11.005},
	author = {Topalian, Suzanne L and Sharpe, Arlene H}
}
