@article {541971,
	title = {ABCB5 Identifies Immunoregulatory Dermal Cells.},
	journal = {Cell Rep},
	volume = {12},
	number = {10},
	year = {2015},
	month = {2015 Sep 8},
	pages = {1564-74},
	abstract = {Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly defined immunomodulatory cell populations poses a barrier to this field. Here, we show that ATP-binding~cassette member B5 (ABCB5) identifies dermal immunoregulatory cells (DIRCs) capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1 (PD-1). Purified Abcb5(+) DIRCs suppressed T~cell proliferation, evaded immune rejection, homed to recipient immune tissues, and induced Tregs in~vivo. In fully major-histocompatibility-complex-mismatched cardiac allotransplantation models, allogeneic DIRCs significantly prolonged allograft survival. Blockade of DIRC-expressed PD-1 reversed the inhibitory effects of DIRCs on T~cell activation, inhibited DIRC-dependent Treg induction, and attenuated DIRC-induced prolongation of cardiac allograft survival, indicating that DIRC immunoregulatory function is mediated, at least in part, through PD-1. Our results identify ABCB5(+) DIRCs as a distinct immunoregulatory cell population and suggest promising roles of this expandable cell subset in cellular immunotherapy.},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2015.08.010},
	author = {Schatton, Tobias and Yang, Jun and Kleffel, Sonja and Uehara, Mayuko and Barthel, Steven R and Schlapbach, Christoph and Zhan, Qian and Dudeney, Stephen and Mueller, Hansgeorg and Lee, Nayoung and de Vries, Juliane C and Meier, Barbara and Vander Beken, Seppe and Kluth, Mark A and Ganss, Christoph and Sharpe, Arlene H and Waaga-Gasser, Ana Maria and Sayegh, Mohamed H and Abdi, Reza and Scharffetter-Kochanek, Karin and Murphy, George F and Kupper, Thomas S and Frank, Natasha Y and Frank, Markus H}
}
