@article {1527668,
	title = {The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection},
	journal = {Cell Reports},
	volume = {31},
	number = {13},
	year = {2020},
	pages = {107827},
	abstract = {
	The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in the PD-1 pathway exhibit impaired CD8+ T cell memory following acute influenza infection, including reduced virus-specific CD8+ T cell numbers and compromised recall responses. PD-1 blockade during priming leads to similar differences early post-infection but without the defect in memory formation, suggesting that timing and/or duration of PD-1 blockade could be tailored to modulate host responses. Our studies reveal a role for PD-1 as an integrator of CD8+ T cell signals that promotes CD8+ T cell memory formation and suggest PD-1 continues to fine-tune CD8+ T cells after they migrate into nonlymphoid tissues. These findings have important implications for PD-1-based immunotherapy, in which PD-1 inhibition may influence memory responses in patients.



	PubMed\&nbsp;DOI

},
	author = {Pauken, KE and Godec, J and Odorizzi, PM and Brown, KE and Yates, KB and Ngiow, SF and Burke, KP and Freeman, G. J. and Haining, WN and Wherry, EJ and Sharpe, A. H.}
}
