@article {1527663,
	title = {Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling},
	journal = {Nature Immunology},
	volume = {20},
	number = {12},
	year = {2019},
	pages = {1668-1680},
	abstract = {
	Lymph node fibroblastic reticular cells (FRCs) respond to signals from activated T cells by releasing nitric oxide, which inhibits T cell proliferation and restricts the size of the expanding T cell pool. Whether interactions with FRCs also support the function or differentiation of activated CD8+\&nbsp;T cells is not known. Here we report that encounters with FRCs enhanced cytokine production and remodeled chromatin accessibility in newly activated CD8+\&nbsp;T cells via interleukin-6. These epigenetic changes facilitated metabolic reprogramming and amplified the activity of pro-survival pathways through differential transcription factor activity. Accordingly, FRC conditioning significantly enhanced the persistence of virus-specific CD8+\&nbsp;T cells in vivo and augmented their differentiation into tissue-resident memory T cells. Our study demonstrates that FRCs play a role beyond restricting T cell expansion{\textemdash}they can also shape the fate and function of CD8+\&nbsp;T cells.



	PubMed\&nbsp;DOI

},
	author = {Brown, FD and Sen, DR and LaFleur, MW and Godec, J and Lukacs-Kornek, V and Danial, NN and Manning, BD and Sharpe, A. H. and Haining, WN and Turley, SJ}
}
