@article {1527657,
	title = {Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade},
	journal = {PNAS},
	volume = {116},
	number = {34},
	year = {2019},
	pages = {16971-16980},
	abstract = {
	Immunotherapy, especially blockade of the PD-1/PD-L1 and CTLA-4 axes, has resulted in durable responses in a range of cancers. However, responses remain heterogeneous among patients. Treatment outcome results from changes in the tumor microenvironment imposed by such blockade. Here, we use immuno-PET and single-cell RNA sequencing to increase our understanding of the dynamics of immune cells and their functional status in the tumor microenvironment in response to PD-1 blockade. Our data provide insights into the dynamics of CD8+\&nbsp;T cells and the functional status of the myeloid compartment in response to PD-1 blockade.



	PubMed\&nbsp;DOI

},
	author = {Rashidian, M and LaFleur, MW and Verschoor, VL and Dongre, A and Zhang, Y. and Nguyen, TH and Kolifrath, S and Aref, AR and Lau, CJ and Paweletz, CP and Bu, X and Freeman, G. J. and Barrasa, MI and Weinberg, RA and Sharpe, A. H. and Ploegh, H.L.}
}
