Balance and imbalance in the immune system: life on the edge.

Citation:

Topalian SL, Sharpe AH. Balance and imbalance in the immune system: life on the edge. Immunity. 2014;41 (5) :682-4.

Date Published:

2014 Nov 20

Abstract:

CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.