# Publications Search Within Results Search Within Results search ## 440 results Show filters filter\_alt Sort by Year of PublicationAlphabetical A-Z sort ## 440 results Download 440 citations download- [BibTeX](/node/1872136/export?format=bibtex) - [EndNote X3 XML](/node/1872136/export?format=endnote8) - [EndNote 7 XML](/node/1872136/export?format=endnote7) - [Endnote tagged](/node/1872136/export?format=tagged) - [Marc](/node/1872136/export?format=marc) - [PubMedId](/node/1872136/export?format=pubmed_id) - [RIS](/node/1872136/export?format=ris) ### 2025 LaFleur M, Milling L, Prathima P, Li V, Lemmen A, Streeter I, Heisig PKS, Derosia N, Riffo E, Xu H, et al. [A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity](https://www.nature.com/articles/s41590-025-02231-6). Nature Immunology. 2025;26. doi:10.1038/s41590-025-02231-6 LaFleur M, Milling L, Prathima P, Li V, Lemmen A, Streeter I, Heisig PKS, Derosia N, Riffo E, Xu H, et al. [A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity](https://www.nature.com/articles/s41590-025-02231-6). Nature Immunology. 2025;26. doi:10.1038/s41590-025-02231-6 - add\_circle do\_not\_disturb\_on Abstract In vivo CRISPR screens in CD8+ T cells have previously uncovered targets for cancer immunotherapy; however, a minority of the genome has been individually annotated, suggesting that additional regulators remain to be discovered. Here we assessed 899 genes... ### 2024 Milling L, Markson S, Tjokrosurjo Q, Derosia N, Streeter I, Hickok G, Lemmen A, Nguyen T, Prathima P, Fithian W, et al. [Framework for in vivo T cell screens](/publications/framework-vivo-t-cell-screens). J Exp Med. 2024;221(4). doi:10.1084/jem.20230699 Milling L, Markson S, Tjokrosurjo Q, Derosia N, Streeter I, Hickok G, Lemmen A, Nguyen T, Prathima P, Fithian W, et al. [Framework for in vivo T cell screens](/publications/framework-vivo-t-cell-screens). J Exp Med. 2024;221(4). doi:10.1084/jem.20230699 - add\_circle do\_not\_disturb\_on Abstract In vivo T cell screens are a powerful tool for elucidating complex mechanisms of immunity, yet there is a lack of consensus on the screen design parameters required for robust in vivo screens: gene library size, cell transfer quantity, and number of mice... Burke K, Chaudhri A, Freeman G, Sharpe A. [The B7:CD28 family and friends: Unraveling coinhibitory interactions](/publications/b7cd28-family-and-friends-unraveling-coinhibitory-interactions). Immunity. 2024;57(2):223–244. doi:10.1016/j.immuni.2024.01.013 Burke K, Chaudhri A, Freeman G, Sharpe A. [The B7:CD28 family and friends: Unraveling coinhibitory interactions](/publications/b7cd28-family-and-friends-unraveling-coinhibitory-interactions). Immunity. 2024;57(2):223–244. doi:10.1016/j.immuni.2024.01.013 - add\_circle do\_not\_disturb\_on Abstract Immune responses must be tightly regulated to ensure both optimal protective immunity and tolerance. Costimulatory pathways within the B7:CD28 family provide essential signals for optimal T cell activation and clonal expansion. They provide crucial... Cohen J, Gouirand V, Macon C, Lowe M, Boothby I, Moreau J, Gratz I, Stoecklinger A, Weaver C, Sharpe A, et al. [Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche](/publications/regulatory-t-cells-skin-mediate-immune-privilege-hair-follicle-stem-cell-niche). Sci Immunol. 2024;9(91):eadh0152. doi:10.1126/sciimmunol.adh0152 Cohen J, Gouirand V, Macon C, Lowe M, Boothby I, Moreau J, Gratz I, Stoecklinger A, Weaver C, Sharpe A, et al. [Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche](/publications/regulatory-t-cells-skin-mediate-immune-privilege-hair-follicle-stem-cell-niche). Sci Immunol. 2024;9(91):eadh0152. doi:10.1126/sciimmunol.adh0152 - add\_circle do\_not\_disturb\_on Abstract Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in these tissues. We developed a technique to restrict genetic recombination to... LaFleur M, Lemmen A, Streeter I, Nguyen T, Milling L, Derosia N, Hoffman Z, Gillis J, Tjokrosurjo Q, Markson S, et al. [X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system](/publications/x-chime-enables-combinatorial-inducible-lineage-specific-and-sequential-knockout). Nat Immunol. 2024;25(1):178–188. doi:10.1038/s41590-023-01689-6 LaFleur M, Lemmen A, Streeter I, Nguyen T, Milling L, Derosia N, Hoffman Z, Gillis J, Tjokrosurjo Q, Markson S, et al. [X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system](/publications/x-chime-enables-combinatorial-inducible-lineage-specific-and-sequential-knockout). Nat Immunol. 2024;25(1):178–188. doi:10.1038/s41590-023-01689-6 - add\_circle do\_not\_disturb\_on Abstract Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consuming and low throughput. We previously developed CHimeric IMmune Editing (CHIME), a CRISPR-Cas9 bone marrow delivery system for... Georgiev P, Benamar M, Han S, Haigis M, Sharpe A, Chatila T. [Regulatory T cells in dominant immunologic tolerance](/publications/regulatory-t-cells-dominant-immunologic-tolerance). J Allergy Clin Immunol. 2024;153(1):28–41. doi:10.1016/j.jaci.2023.09.025 Georgiev P, Benamar M, Han S, Haigis M, Sharpe A, Chatila T. [Regulatory T cells in dominant immunologic tolerance](/publications/regulatory-t-cells-dominant-immunologic-tolerance). J Allergy Clin Immunol. 2024;153(1):28–41. doi:10.1016/j.jaci.2023.09.025 - add\_circle do\_not\_disturb\_on Abstract Regulatory T cells expressing the transcription factor forkhead box protein 3 mediate peripheral immune tolerance both to self-antigens and to the commensal flora. Their defective function due to inborn errors of immunity or acquired insults is associated... ### 2023 Denize T, Jegede O, Matar S, El Ahmar N, West D, Walton E, Bagheri AS, Savla V, Nabil Laimon Y, Gupta S, et al. [PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear Cell Renal Cell Carcinoma Patients](/publications/pd-1-expression-intratumoral-regulatory-t-cells-associated-lack-benefit-anti-pd). Clin Cancer Res. 2023. doi:10.1158/1078-0432.CCR-23-2274 Denize T, Jegede O, Matar S, El Ahmar N, West D, Walton E, Bagheri AS, Savla V, Nabil Laimon Y, Gupta S, et al. [PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear Cell Renal Cell Carcinoma Patients](/publications/pd-1-expression-intratumoral-regulatory-t-cells-associated-lack-benefit-anti-pd). Clin Cancer Res. 2023. doi:10.1158/1078-0432.CCR-23-2274 - add\_circle do\_not\_disturb\_on Abstract PURPOSE: PD-1 expression on CD8+TIM-3-LAG3- tumor-infiltrating cells predicts positive response to PD-1 blockade in metastatic clear cell renal cell carcinoma (mccRCC). Since PD-1 signaling inhibition in regulatory T cells (Tregs) augments their... Rowe J, Elia I, Shahid O, Gaudiano E, Sifnugel N, Johnson S, Reynolds A, Fung M, Joshi S, LaFleur M, et al. [Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade](/publications/formate-supplementation-enhances-antitumor-cd8-t-cell-fitness-and-efficacy-pd-1). Cancer Discov. 2023;13(12):2566–2583. doi:10.1158/2159-8290.CD-22-1301 Rowe J, Elia I, Shahid O, Gaudiano E, Sifnugel N, Johnson S, Reynolds A, Fung M, Joshi S, LaFleur M, et al. [Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade](/publications/formate-supplementation-enhances-antitumor-cd8-t-cell-fitness-and-efficacy-pd-1). Cancer Discov. 2023;13(12):2566–2583. doi:10.1158/2159-8290.CD-22-1301 - add\_circle do\_not\_disturb\_on Abstract UNLABELLED: The tumor microenvironment (TME) restricts antitumor CD8+ T-cell function and immunotherapy responses. Cancer cells compromise the metabolic fitness of CD8+ T cells within the TME, but the mechanisms are largely unknown. Here we demonstrate... Collier J, Pauken K, Lee C, Patterson D, Markson S, Conway T, Fung M, France J, Mucciarone K, Lian C, et al. [Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice](/publications/single-cell-profiling-reveals-unique-features-diabetogenic-t-cells-anti-pd-1). J Exp Med. 2023;220(10). doi:10.1084/jem.20221920 Collier J, Pauken K, Lee C, Patterson D, Markson S, Conway T, Fung M, France J, Mucciarone K, Lian C, et al. [Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice](/publications/single-cell-profiling-reveals-unique-features-diabetogenic-t-cells-anti-pd-1). J Exp Med. 2023;220(10). doi:10.1084/jem.20221920 - add\_circle do\_not\_disturb\_on Abstract Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer immunotherapy. A better understanding of how these iatrogenic diseases compare with naturally arising autoimmune diseases is needed for treatment and monitoring of irAEs. We... Kurmi K, Liang D, Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris I, Yao C-H, Park JS, et al. [Metabolic modulation of mitochondrial mass during CD4 T cell activation](/publications/metabolic-modulation-mitochondrial-mass-during-cd4-t%C2%A0cell-activation). Cell Chem Biol. 2023;30(9):1064–1075.e8. doi:10.1016/j.chembiol.2023.08.008 Kurmi K, Liang D, Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris I, Yao C-H, Park JS, et al. [Metabolic modulation of mitochondrial mass during CD4 T cell activation](/publications/metabolic-modulation-mitochondrial-mass-during-cd4-t%C2%A0cell-activation). Cell Chem Biol. 2023;30(9):1064–1075.e8. doi:10.1016/j.chembiol.2023.08.008 - add\_circle do\_not\_disturb\_on Abstract Mitochondrial biogenesis initiates within hours of T cell receptor (TCR) engagement and is critical for T cell activation, function, and survival; yet, how metabolic programs support mitochondrial biogenesis during TCR signaling is not fully understood... Park JS, Gazzaniga F, Kasper D, Sharpe A. [Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy](/publications/microbiota-dependent-regulation-costimulatory-and-coinhibitory-pathways-innate). Exp Mol Med. 2023;55(9):1913–1921. doi:10.1038/s12276-023-01075-0 Park JS, Gazzaniga F, Kasper D, Sharpe A. [Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy](/publications/microbiota-dependent-regulation-costimulatory-and-coinhibitory-pathways-innate). Exp Mol Med. 2023;55(9):1913–1921. doi:10.1038/s12276-023-01075-0 - add\_circle do\_not\_disturb\_on Abstract Our bodies are inhabited by trillions of microorganisms. The host immune system constantly interacts with the microbiota in barrier organs, including the intestines. Over decades, numerous studies have shown that our mucosal immune system is dynamically... Bod L, Kye Y-C, Shi J, Triglia ET, Schnell A, Fessler J, Ostrowski S, Von-Franque M, Kuchroo J, Barilla R, et al. [B-cell-specific checkpoint molecules that regulate anti-tumour immunity](/publications/b-cell-specific-checkpoint-molecules-regulate-anti-tumour-immunity). Nature. 2023;619(7969):348–356. doi:10.1038/s41586-023-06231-0 Bod L, Kye Y-C, Shi J, Triglia ET, Schnell A, Fessler J, Ostrowski S, Von-Franque M, Kuchroo J, Barilla R, et al. [B-cell-specific checkpoint molecules that regulate anti-tumour immunity](/publications/b-cell-specific-checkpoint-molecules-regulate-anti-tumour-immunity). Nature. 2023;619(7969):348–356. doi:10.1038/s41586-023-06231-0 - add\_circle do\_not\_disturb\_on Abstract The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA... - Previous page chevron\_left - [1](?page=0 "Current page") - [2](?page=1 "Go to page 2") - [3](?page=2 "Go to page 3") - [ Last page 37 ](?page=36 "Go to last page") - [ Next page chevron\_right ](?page=1 "Go to next page")